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Hirschome • 6 years ago

I have MTHFR C667T...one copy....but after taking out my amalgams, I became very sick due to mercury poisoning.  My homocysteine was 4.  Too low can also be bad.  Dr. Kendall Stewart, in Austin Texas, (neurobiologix.com) has works with thousands of ASD children with low homocysteine levels and helped raise them to normal with supplements like methylfolate, methycobalamin, P5P, and TMG.   MTHFR enzyme mutation makes it difficult to get rid of toxins because the methylation cycle is interrupted.  One study suggests that as high as 94-98% of ASD children have one or more copies of MTHFR, so they can't get rid of toxins like those without the mutation.  40-60% of the population have this gene.  I started taking methylated B vitamins and now my homocysteine is 6.3...normal and all my side effects of mercury poisoning are gone and I have energy ,think clearly, and my pain disappeared that felt like fibermyalgia.  Don't take the fake forms of B vitamins if you have MTHFR.  In 2005, my reproductive endocrinologist put me on Folgard 2.2mg (fake B vitamins) and my babies still died after seeing heart beats.  Most likely blood clots killed the babies because my husband carries MTHFR A1298C.  I have 5 kids.  Two have C667T/A1298C.  One with C667T and one with A1298C.  We are all taking methylated B vitamins and my two with the C667T/A1298C especially need to take them to lower their homocysteine levels.  Don't just go out and start taking folic acid and B12....they need to be methylated. 

Malc Simmonds • 6 years ago

Hi – thanks for that feedback. I like the way you have tracked down the route you and your family need to follow. Kudos. And interesting point about the methylated supplements.

Sorry about the lost babies :-(

Take care, Malc

Joan T • 4 years ago

Excess arginine uses up methyl groups as it is used to make creatine, raising homocysteine. Best thing is to avoid peanut butter, seeds, nuts, and grains, and eat lots of yogurt, beans, and fish.

Malc Simmonds • 4 years ago

Thanks for the input, Joan. :)

Joan T • 4 years ago

I've been researching the effects of high arginine and low lysine, and it covers pretty much every health problem I can think of. I'm glad your longevity-type blog doesn't push arginine-a lot of them do! I put this information up on a website-it's really helpful, can I post it here?

Malc Simmonds • 4 years ago

Sure, Joan - post the link. Thanks :)

Joan T • 4 years ago
Malc Simmonds • 4 years ago

:Ta! )

Joan T • 4 years ago

If you get a chance to look at the site, I'd appreciate any comments you might have.

ruth • 4 years ago

I have pyroluria. How does this effect methylation? As a consequence, I have to take high doses of zinc and B6 daily to keep my levels up. My homocysteine level is 7.5, I'm hypo thyroid and my c reactive protein is 6.9. Should I take TMG, SAMe and Methionine? Could the high homocysteine be a consequence of continually being drained of zinc and B6? Are there foods that people should or shouldn't eat that effect homocysteine levels?

Malc Simmonds • 4 years ago

Hi Ruth - wow! You have all the figures there! I think you want to consult with a practitioner because as you take those supplements you will want to be monitoring the results via appropriate blood tests.

I know of two in the US - if that's where you are: Philip Miller in California and Terry Grossman in Denver. I hope that helps :)


whataboutthat • 7 years ago

"Enough study has been done to conclude with reasonable certainty that
taking B-vitamins to lower homocysteine levels will not lower the
incidence or heart attacks or strokes except for people with
homocystinurea. Nor is it advisable to do routine screening for
homocysteine levels"

Malc Simmonds • 7 years ago

Yes, this is one of the views. Thanks for input.



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Noexcuses • 7 years ago

Isn't  N-acetyl cysteine(an amino acid) combined with the amino acids glutamic acid and glycine the precursors of Glutathione-the king of antioxidants?  And isn't homocysteine derived from cysteine?  Does taking B6, B12 and folic acid negate this formation?

Cindy • 7 years ago

first of all, there is a difference between homocysteine and cysteine alone. i will explain it to you:
Homocysteine is a homologue of the amino acid cysteine, differing by an additional methylene (-CH2-) group. It is biosynthesized from methionine by the removal of its terminal Cε methyl group. Homocysteine can be recycled into methionine or converted into cysteine with the aid of B-vitamins. So basically you need the b vitamins for the removal of the homocysteine through methylation .
And about Gluthatione you are right, but for eg i had a low glutathione lvl and i took the reduced form and now my levels are back to normal, but if you can find NAC and the other 3 amino acids go ahead and take them, they will not do you any harm.

cindy • 7 years ago

Is sam-e and b6,b12 and zinc enough to keep the methylation at it's best?

Malc Simmonds • 7 years ago

Hi Cindy

Basically - you need, ideally, to test your blood to see what you need if anything: take the supplements: and retest to see if you fixed it.

This is not an exact science especially so as we are at the cutting edge here. But the broad facts are right - now you have to apply them to yourself. OK - it's a bit experimental, it's true: but that's the best option - and I'd say that's a good option!

I just had 80 or so blood tests done when in California, and it ran to $500/£350 or so. Not bad. I went through LIfe Extension - lef.org. They are US-wide.



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Manjit Bhurji • 7 years ago

very informative

Heather Bowell • 7 years ago

Tetsing for homocysteine is a good indicator of an impending heart attack.

The Health Guru • 8 years ago

If you were to take your time and realize that life is short you will be able to understand the true meaning of the message.

Malc • 8 years ago

Sounds a bit 'preachy'... but thanks for taking the time to comment.


sammy @ alzheimers • 9 years ago

Longevity is all well and good, as long as it is accompanied by well being. As a society we need to embrace a new association with planet earth.

SubersivusMagnus • 4 years ago

...."As a society we need to embrace a new association with planet earth." ......
That is a statement which means absolutely nothing.