Disqus - Latest Comments for saxonov

Re: I don’t want a 23andMe — I want the real genetic tests

helixhealth — Sat, 20 Sep 2008 22:30:38 -0000

Not really well established if you rely on the 3 papers which published different results and penetrance rates all over the place....

I am writing the authors of the gene tests article, b/c there is hype in it.

-Steve
www.thegenesherpa.blogspot.com

Re: I don’t want a 23andMe — I want the real genetic tests

saxonov — Sat, 20 Sep 2008 17:42:38 -0000

Yeah, the high penetrance is very well established. So there are many references.
For example, here is a pretty big paper that came out in July: http://www.ncbi.nlm.nih.gov/pubmed/18539534
Also, this is a good resource:
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?b...
(scroll down to penetrance).

Re: I don’t want a 23andMe — I want the real genetic tests

kevinfischer — Sat, 20 Sep 2008 16:25:31 -0000

Do you have a source for that? I was going off of Steve Murphy's post here: http://thegenesherpa.blogspot.com/2008/09/lrrk2...

Re: I don’t want a 23andMe — I want the real genetic tests

saxonov — Sat, 20 Sep 2008 14:12:53 -0000

One clarification re "I don’t particularly care about a mutation that gives me a slightly increased risk for a disease. " The increased risk is not slight.

This mutation is actually quite penetrant. It increases one's baseline risk by a factor of about 20, which is why Sergey said that his chances of developing PD are between 20 and 80%.