http://disqus.com/people/saxonov/enSat, 20 Sep 2008 17:42:38 -0000http://www.thinkgene.com/i-dont-want-a-23andme-i-want-the-real-genetic-tests/#comment-2501694Yeah, the high penetrance is very well established. So there are many references.<br>For example, here is a pretty big paper that came out in July: <a href="http://www.ncbi.nlm.nih.gov/pubmed/18539534" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18539534</a><br>Also, this is a good resource:<br><a href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lrrk2#lrrk2.Clinical_Description" rel="nofollow">http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?b...</a><br>(scroll down to penetrance).saxonovSat, 20 Sep 2008 17:42:38 -0000http://www.thinkgene.com/i-dont-want-a-23andme-i-want-the-real-genetic-tests/#comment-2454950One clarification re "I don’t particularly care about a mutation that gives me a slightly increased risk for a disease. " The increased risk is not slight.<br><br>This mutation is actually quite penetrant. It increases one's baseline risk by a factor of about 20, which is why Sergey said that his chances of developing PD are between 20 and 80%.saxonovSat, 20 Sep 2008 14:12:53 -0000