I think the cut off could be illustrated better, even though I like the idea of this strip. As most comments here show - and my own experience wasn't far off, opened the comic in an extra-tab to proof it wasn't broken and then read the title and got the punchline - this way it isn't obvious that you meant it to iterate on and on. Maybe scaling would have helped. The sub-strip stepwise getting smaller, but that would imply a loss of relevance.
I'm also having a problem with reading-directions again: down, right, right, down, major down, down, right, right, down, major down... Especially the "major down" was quite a problem. At least I was confused with the directions. The similarity of the pictures in the first column made me believe I had to read downwards only, in columns. Indicating directions with arrows or something like that anyways seems like an unsatisfactory solution to me. There must be a way to point the direction more subtle. Scaling again would have helped maybe, because it would have distinguished the sub-strips from each other.
I just gave two stars as it is now, but I feel it would have gotten far more if your idea would have had a better optical equivalent.