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  • Steven Murphy M.D.
  • Steven Murphy MD
  • Steven Murphy MD

Steven Murphy MD

1 month ago

in The Problem with “Health Information Technology” in Two Paragraph Quotes on Think Gene
Jay,
I think it is because you made reference that it was just you and 2 others working on Hello Health......which seemed revolutionary rather than corporate and hyped......
But the bus made things much clearer for us.
Good luck with your company.
-Steve

1 month ago

in jay parkinson + md + mph = doctor in brooklyn - UCLA leaks Farah Fawcett's medical information to the Inquirer on Jay Parkinson + MD + MPH
Agreed. Jay, you and I are on the same page. Even if you didn't agree when I sent Mr. Tindall your way.

-Steve
www.thegenesherpa.blogspot.com
1 reply
Jay Parkinson, MD's picture
Jay Parkinson, MD What do you mean Steve? You lost me...sorry.

1 month ago

in The Problem with “Health Information Technology” in Two Paragraph Quotes on Think Gene
I would say with the addition of my patients' records, lab results and even EKGs and radiology on my iphone, you have already proven yourself to be invaluable.

-Steve
1 reply
Andrew Heh, I haven't even written anything yet. These features are merely the natural consequences of two scattered month of purchased infrastructure.

:)

4 months ago

in 23andMe in the Medical Space on Think Gene
Ouch,
I have never stated that 23andME should be represented by this disclaimer I suggested.

DNA retesting should not be prompted by whether the first test was cheap or not. It should be guided by how well do you trust the labs results. If the test results are not to be trusted, then even the public should not place their trust in them. Most tests are reliable.

As for your right to know your DNA......sure. But does a company have the ability to give you a clinical interpretation without accepting regulations THAT WE ALL HAVE TO ABIDE BY when we give clinical interpretation????

What is clinical interpretation? Descriptions which MAY be interpreted by the average person as able to be used for healthcare guidance. Plain and simple.

Have your As, Gs, Cs and Ts.......just skip the interpretation and my argument will be destroyed.

-Steve

www.thegenesherpa.blogspot.com

4 months ago

in 23andMe in the Medical Space on Think Gene
Why should you ever have to retest DNA?
CLIA certification is a start, NYS and Ca State registration is a plus, ISO certification is even better.

Some states allow patients to order medical tests, some don't. Why not just call these few SNPs what they are, medical tests and let the law decide who orders what?

The disclaimer should read:" We are running a cheap knock off production and charging you entirely too much for it. In addition we are stealing your data and selling to the highest bidder. If you STILL want to use us rather than have your data safely protected from others looking to obtain your data...Heck, sign on up and join the conversation"

This is a clear move towards Clinical Applicability, stop fooling yourself.

-Steve
www.thegenesherpa.blogspot.com
1 reply
Anon in Montreal You should retest DNA because the test could be wrong! Contamination, untrained personnel, software errors, hackers, etc. But a company is allowed to offer a cheap novelty grade test and let others charge more for "certain enough to be actionable" tests.

My Casio says "not for use in diving", even though everyone knows it is waterproof to 100m. I use it when I snorkel. But when I dive, I pay extra for the SCUBA certified equipment. Should Casio be banned from making waterproof watches?

Your claim that 23andme is stealing data is (1) false, since their terms of consent are clearly spelled out; and (2) slanderous.

Your claim that they are charging too much is interesting. How much would YOU charge me to get the same tests and detailed background info I got from 23andme?

Face it: more people are interested in DTC companies' services than yours. Your attempt to use the government to prevent people from cheaply accessing their genetic data is unethical. YOU don't get to decide if I am allowed to access my OWN data.

4 months ago

in Photographic Guide to Myriad’s BRCA Testing Kit on Think Gene
A perfect Genomic Sequence is only 1/3,000,000,000th of the way there......we need clinical correlation with each of those base pairs......
We already have some good clinical correlation with MOST family history.

-Steve
www.thegenesherpa.blogspot.com

4 months ago

in Legal Details of a USA Certificate of Confidentiality in Medical Research on Think Gene
@ Anonoymous......
Funny, last time I checked, that's what people are scared of "Involuntary Disclosure" through legal stuff.....As for a NON-FOR-PROFIT, releasing data FOR PROFIT MOTIVE is not in the spirit of that company......However, DTC FOR PROFIT companies will release and have Neither HIPAA or Certificate protections......

Thus, I say....stay away from any company who can SELL your genome without your approval.....I.E. 23andMe, Decode, Navigenics, DNADynasty, et.al.

-Steve
www.thegenesherpa.blogspot.com

4 months ago

in Coriell PMC Launches Web Portal on Think Gene
Points:
1. As for nationwide availability, Navi can't test people in NY or several other states where it is ILLEGAL to perform DTC testing
2. Navigenics and 23andME test results did take longer than immediately to come back. Most of these took a month or so
3. I think they may be working on the email and video consent stuff.....I think.

-Steve
www.thegenesherpa.blogspot.com

5 months ago

in The Great American Health Insurance Compromise on Think Gene
Now include, "Getting There From Here" by Atul Gawande in this month's edition of the New Yorker and you will see where we soon shall be in about 6 months. AHIP gave equally to both parties....forced to carry health insurance? Why not. We are forced to carry Car Insurance
:-P

-Steve
www.helixhealth.org

5 months ago

in Response to “That’s Just Boilerplate” comment on Think Gene
Not all science makes the cut to become medical care fellas.....that's just how it is.....Scientific validity is no substitute for clinical utility......
1 reply
Andrew Yates's picture
Andrew Yates The archetypal example of a diagnostic scientific success but clinical failure is Prostate Specific Antigen (PSA) testing, which, while considered one of the most effective tumor markers in human oncology, is not recommended or tenuously recommend by several prominent medical advisory boards because the treatments for prostate cancer are often more physiologically destructive than the disease itself. In short, "minor" prostate cancer is common, but generally, something else kills you before it advances enough to become a problem.

So, prostate cancer screening can have a net negative clinical outcome (particularly for elderly patients with less than ten years of expected lifespan) despite its successful use to diagnose prostate cancer.

5 months ago

in New Physician on Think Gene
Nice Pic....

6 months ago

in Helicos Error Rates on Think Gene
Agreed.
-Steve

6 months ago

in The Gift of Ancestry at 23andMe on Think Gene
Love it! Buy Rubenstein.......Medicine? Ask Marketing :)

-Steve
1 reply
Andrew Yates's picture
Andrew Yates Haha, hey, they asked. What do I look like, a journalist? Silly.

But seriously, I do like this feature, and it is something worth owning if one was looking to purchase a novelty web service. I am absolutely 100% for 23andMe the novelty web service. If it were an affordable impulse purchase for my friends and family, I'd encourage everybody to buy one for that reason. And if you have $400, sure, why not buy it? It's the best novelty genomic web service available, and it is pretty cool.

7 months ago

in Absence of “High Penetrance” in SNP Genomic Services on Think Gene
The official line is that low penetrance genes are more common and thus more relevant. From Dr. Nierenberg of Navigenics:

“In the case of the BRCA genes, only a relatively small proportion of the population – as low as 5% - carry one or more of these genes. We are focused on SNPs that are apparent within whole populations. We make it clear in our literature that we do not test for this type of gene.”

Yeah, and it just so happens that the 10% (not 5%) actually has medically actionable validity....

-Steve

7 months ago

in 23andMe on Think Gene
I would look for confirmation from 23andMe, before I believe that they ALWAYS destroyed the samples.....

-Steve

7 months ago

in Navigenics’ Medical Advice on Think Gene
Andrew,
I am deeply disturbed by that company approved press release. This is very troublesome. Walking the line between medicine and not medicine is a game that is played by several companies, and frankly Navigenics has now just entered that fringe realm.......

-Steve
www.thegenesherpa.blogspot.com

7 months ago

in The Unusually High Standards of Genomics on Think Gene
Andrew,
If they didn't want the scrutiny, they could have picked another field.....Geneticists have been picky from the very beginning, Medical geneticists even more so........They entered a field with several barriers to entry and now you are complaining about the scrutiny which everyone in this field faces? Maybe 23andMe is off the hook if they decide only to do ancestry and non-medical risk SNPs, but by putting medical risk SNPs on their chip....guess what? They enter the field too.......Welcome to the Jungle......

-Steve
www.thegenesherpa.blogspot.com

8 months ago

in New journal shows half-broken gene is enough to cause cancer on Think Gene
Great post Josh! We have suspected this to be the case clinically. It is nice to see some evidence supporting this anecdote.

-Steve
www.thegenesherpa.blogspot.com

8 months ago

in Gene Sherpa Reports Systemic Medical Insurance Fraud on Think Gene
Wow! Drew. I gues you are mad because I said Silly-Con Valley Types......
No one said Counseling would die with counselors. I just wanted to provide a legal billing option for genetics departments. That's all. BTW, can your python program give a tissue or a hug? What about a warm, "It's going to be ok". Until we all mutate into klingons or vulcans, your solution is only for the Millenial Generation.

XOXO

-Gossip Girl

9 months ago

in Translating “Gene Sherpa” to “Silicon Valley” on Think Gene
Thanks for the motivation!
-Steve

9 months ago

in Media-Induced Confusion about LRRK2 Discussed in 23andMe Forums on Think Gene
Nice wrap up Drew. I am sure they will benefit from this. Did you tell him about mutations like me???

-Steve
www.thegenesherpa.blogspot.com
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