I may be uncreative and boring, but I'd like to see CAD that is stable, does what it's supposed to do well without excessive flashy capability that's not really capability because it doesn't work. The CAD would be easy to use with powerful tools that a designer NEEDS and uses everyday to save time and accomplish his job, which is to design accurate, functional tools and/or products.
I think that designers will still want tangible ways to manipulate models so some sort of 3D space navigator will exist, it just might be a lot different. Possibly, it will also be used to "mold" the part-kind of a squishy (but firm) shape that when poked or squeezed does the same to the model.