http://disqus.com/by/neandrothal/enFri, 10 Oct 2008 12:30:24 -0000http://www.thinkgene.com/quick-quiz-are-you-competitant-to-understand-genomic-tests/#comment-2982741<p>Just a quick note: these numbers are *not* accurate numbers for Parkinson's disease. They're the same (fake) numbers as in the Yudkowsky example. I hope people don't switch the 80% numbers around in their heads and think that 80% of people with Parkinson's have LRRK2 G2019S, though it is true that some studies report that people with LRRK2 G2019S may have up to an 80% lifetime risk of Parkinson's (i.e. penetrance of the disease given the mutation = up to 80%).</p>neandrothalFri, 10 Oct 2008 12:30:24 -0000http://www.thinkgene.com/i-dont-want-a-23andme-i-want-the-real-genetic-tests/#comment-2521310<p>According to the Sherpa's own blog post (<a href="http://thegenesherpa.blogspot.com/2008/09/lrrk2-and-parkinson-disease.html):" rel="nofollow noopener" target="_blank" title="http://thegenesherpa.blogspot.com/2008/09/lrrk2-and-parkinson-disease.html):">http://thegenesherpa.blogsp...</a></p><p>"And even if you are Jewish, the penetrance of this mutation is 24 to 85%."</p><p>Sergey Brin is Jewish. Penetrance is defined as the probability of disease given the mutation. "24 to 85%" is completely consistent with Brin's 20-80% quote.</p><p>So Sergey's post is completely relevant. He has found out information about himself that according to studies *specific to his ethnicity* give him a 20-80% chance of getting Parkinson's, a dramatic increase above the &lt;1% chance in the general population.</p>neandrothalMon, 22 Sep 2008 12:12:52 -0000