<?xml version="1.0" encoding="utf-8"?>
<rss xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title>Disqus - Friends of MacSmiley</title><link>http://disqus.com/by/MacSmiley/</link><description></description><atom:link href="http://disqus.com/MacSmiley/friends.rss" rel="self"></atom:link><language>en</language><lastBuildDate>Fri, 19 Apr 2013 21:06:17 -0000</lastBuildDate><item><title>Re: Origin of the Species: Evolutionary diets</title><link>(u'http://huntgatherlove.com/content/origin-species-evolutionary-diets',%20645047269L)#comment-645047269</link><description>&lt;p&gt;"&lt;br&gt;where scientific interpretations conflict with what the Bible says, I choose the Bible,"  This is an indefensible position to take.&lt;/p&gt;&lt;p&gt;If the bible was written by humans and humans did not appear until the 6th day how do we know what happened on days 1-5?&lt;/p&gt;&lt;p&gt;Which version of the bible are you talking about?  There have been numerous "official" versions published with massive edits occurring over the centuries.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 09 Sep 2012 09:26:44 -0000</pubDate></item><item><title>Re: Origin of the Species: Evolutionary diets</title><link>(u'http://huntgatherlove.com/content/origin-species-evolutionary-diets',%20645047906L)#comment-645047906</link><description>&lt;p&gt;"&lt;br&gt;"he’s a huckster who really doesn’t give a fuck what the premise is as &lt;br&gt;long as it’s promoting how thin you will be eating a lot of fat &amp;amp; &lt;br&gt;meat despite the fact that he is over 300lbs and lost just as much &lt;br&gt;weight doing ornish as he did on atkins before getting fat again after &lt;br&gt;both...This is not a guy who should be a leader in an evidence-based or even &lt;br&gt;knowledge-based movement, he’s more suited to his role as some eccentric&lt;br&gt;character with a hypocritical physique who does a podcast where you can&lt;br&gt;promote your latest scam while he lobs you softball question."&lt;/p&gt;&lt;p&gt;What is untrue about that post?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 09 Sep 2012 09:28:23 -0000</pubDate></item><item><title>Re: Origin of the Species: Evolutionary diets</title><link>(u'http://huntgatherlove.com/content/origin-species-evolutionary-diets',%20645049740L)#comment-645049740</link><description>&lt;p&gt;Explain why he was picked to moderate a panel on "safe starches"  when his position on that is clear?  He is a VLCHF proponent and will NEVER change his opinion in spite of the fact that EVERY N=1 experiment he has tried so far has failed and his set point has increased to 279lbs.  If one can talk the talk but no walk the walk that person should not be in a position of influence.&lt;br&gt;&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 09 Sep 2012 09:32:03 -0000</pubDate></item><item><title>Re: Origin of the Species: Evolutionary diets</title><link>(u'http://huntgatherlove.com/content/origin-species-evolutionary-diets',%20645458419L)#comment-645458419</link><description>&lt;p&gt;the question is this - what is untrue about the post??  Please answer if you can.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 09 Sep 2012 20:45:00 -0000</pubDate></item><item><title>Re: 6-Month Lipid Panel Update On My Nutritional Ketosis N=1 Experiment</title><link>(u'http://livinlavidalowcarb.com/blog/6-month-lipid-panel-update-on-my-nutritional-ketosis-n1-experiment/16449',%20700463122L)#comment-700463122</link><description>&lt;p&gt;How can you not see how it looks to post your extremely alarming lipid results, mention that you're working with a doctor you trust who thinks said results indicate you are doing tremendous damage to yourself, and, IN THE SAME POST, talk about how you're writing a book to help people interpret their own lipid results?&lt;/p&gt;&lt;p&gt;Doesn't listening to Dr. Dayspring (which is a GOOD thing) and considering what he is saying as arguably valid disqualify you from writing such a book? How can someone not sure how to interpret their own results help others?&lt;/p&gt;&lt;p&gt;Now, it is possible you could go through this whole experience, learn a lot, and then, if you've clearly learned some good information that helped, end up writing a book about what you've learned. But that's not what you're doing. You've already signed to do the book and have a deadline, while you sit there confused by your own results. This is madness.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 04 Nov 2012 15:13:36 -0000</pubDate></item><item><title>Re: 6-Month Lipid Panel Update On My Nutritional Ketosis N=1 Experiment</title><link>(u'http://livinlavidalowcarb.com/blog/6-month-lipid-panel-update-on-my-nutritional-ketosis-n1-experiment/16449',%20700915384L)#comment-700915384</link><description>&lt;p&gt;Jimmy - you said "My blood work from October 2005 showed my lipid profile as nearly ideal with HDL at 71, triglycerides at 57, VLDL at 11, LDL at 119, and total cholesterol at an acceptable 201. This was what my numbers looked like after livin’ la vida low-carb for about 22 months and I was proud to see them doing so well."&lt;/p&gt;&lt;p&gt;What have you changed since then and why don't you go back to what you were doing then??&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Mon, 05 Nov 2012 10:55:10 -0000</pubDate></item><item><title>Re: 6-Month Lipid Panel Update On My Nutritional Ketosis N=1 Experiment</title><link>(u'http://livinlavidalowcarb.com/blog/6-month-lipid-panel-update-on-my-nutritional-ketosis-n1-experiment/16449',%20701267022L)#comment-701267022</link><description>&lt;p&gt;Why did you change what was working then and why do you think it won't work now??&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Mon, 05 Nov 2012 19:22:43 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20858121949L)#comment-858121949</link><description>&lt;p&gt;Improving his lipid numbers???  He must be joking - his lipid numbers have gotten WORSE not better - His LDL-P and his ApoB numbers are EXTREMELY dangerous to his health yet he chooses to IGNORE them.&lt;/p&gt;&lt;p&gt;Look at ahis blood sugar levels - all  over the place EVEN with berberine - blame it on his less than 3 day fast - he has an excuse for everything&lt;/p&gt;&lt;p&gt;"What’s next? I would like to have another NMR Lipoprofile test run to see what’s going on with my LDL particles and particle size. A very generous fan of my work paid for me to have genetic testing of my DNA to see if I have familial hypercholesterolemia or not. I don’t think I do, but the test results due in on April 15, 2013 will confirm or deny. Stay tuned! Another wonderful reader has agreed to pay the costs to have my hair tested for minerals. I’m currently letting it grow out to the required 1 to 1 1/2 inches for the test and will scalp the back of my head to do this test. It may not be long enough until mid-May, but I look forward to see the results from this test when I can get it done. I’m still very interested in doing more testing in the coming months, so let me know what you’d like to see me have done. And if you would like to contribute towards helping me run more health tests in the coming months, then feel free to e-mail me what tests you would like to see along with making a donation towards this effort through PayPal.&lt;/p&gt;&lt;p&gt;Hair analysis - OMG - This man is a WHORE!!  He will have ANY test done if someone pays for it.  I sense some serious psychological problems here.&lt;/p&gt;&lt;p&gt;Now that he is down to 231 what next - how will he shift over to maintenance?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Tue, 09 Apr 2013 20:38:43 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20858181099L)#comment-858181099</link><description>&lt;p&gt;&lt;a href="http://sanfrancisco.cbslocal.com/2012/05/08/healthwatch-reno-gambling-on-disease-prevention/" rel="nofollow noopener" target="_blank" title="http://sanfrancisco.cbslocal.com/2012/05/08/healthwatch-reno-gambling-on-disease-prevention/"&gt;http://sanfrancisco.cbsloca...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;“We look at Body Mass Index, blood pressure, smoking history. We look at a basic lipid panel. We look at sugars. We do a metabolic syndrome calculation,” said Dr. James Greenwald, with Specialty Health. If there is a suggestion of increased risk, Greenwald said, physicians look further with something called “advanced lipid testing.”&lt;/p&gt;&lt;p&gt;Dr. Tara Dall, a Wisconsin-based lipidologist who is working on the Reno project, said it is very important to test for the right things. Many at-risk individuals are missed because of improper tests, she said.&lt;/p&gt;&lt;p&gt;“Half of all people who have cardiovascular events have normal cholesterol levels,” said Dall, who recommends checking lipoproteins, the particles in blood that carry cholesterol and triglycerides. She said it’s not the passengers (the cholesterol), it’s the cars (the particle number) that is most important.&lt;/p&gt;&lt;p&gt;“It’s the (lipoproteins) that really define risk,” said Dall, adding that lipids give a window into diabetes because they began to change long before sugar levels get elevated.&lt;/p&gt;&lt;p&gt;The first behavioral change is diet. Specialty Health prescribes a “Paelo” low-carb diet – with basic foods and nothing processed.&lt;/p&gt;&lt;p&gt;“Certain foods make you sick,” said science journalist Gary Taubes. “If you don’t eat them you won’t be sick, you won’t be fat, you won’t be pre-diabetic, or diabetic, you won’t get heart disease.”&lt;/p&gt;&lt;p&gt;Exercise is another important consideration when treating insulin resistance. Exercise raises the HDL (good) cholesterol and promotes insulin sensitivity in muscle.&lt;/p&gt;&lt;p&gt;Weight loss, even just 5% of body weight, can have a significant impact on metabolism – especially dangerous belly fat.&lt;/p&gt;&lt;p&gt;And in some cases, Specialty Health prescribes medication, such as Metformin, which promotes insulin sensitivity and fights the progression of insulin resistance and/or the development of Type 2 diabetes."&lt;/p&gt;&lt;p&gt;Notice there is NO mention of statin drugs in this article!!&lt;/p&gt;&lt;p&gt;SO - according to Dr Dall high LDL-P is a precursor to diabetes!!&lt;/p&gt;&lt;p&gt;My oh my what will Jimmy say/do?? How do you reduce LDL-P while on a very high saturated diet??&lt;/p&gt;&lt;p&gt;Dr Dayspring told JM to REDUCE his saturated fat intake IMMEDIATELY and if his LDL-P doesn't drop start on a statin regimen. After all even Robb Wolf uses statins now.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Tue, 09 Apr 2013 21:57:41 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20858825254L)#comment-858825254</link><description>&lt;p&gt;Take awayrthe berberine and he's definitely pre diabetic&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Wed, 10 Apr 2013 13:14:58 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20858860212L)#comment-858860212</link><description>&lt;p&gt;Here's a link to the full paper on red meat, carnitine, TMAO and CVD&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.scribd.com/doc/134715081/nm-3145" rel="nofollow noopener" target="_blank" title="http://www.scribd.com/doc/134715081/nm-3145"&gt;http://www.scribd.com/doc/1...&lt;/a&gt;&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Wed, 10 Apr 2013 13:52:33 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20858899585L)#comment-858899585</link><description>&lt;p&gt;Delusion reigns at livin la vida low carb&lt;/p&gt;&lt;p&gt;&lt;a href="http://livinlavidalowcarb.com/blog/jimmy-moores-n1-experiments-nutritional-ketosis-day-301-330/18195#comments" rel="nofollow noopener" target="_blank" title="http://livinlavidalowcarb.com/blog/jimmy-moores-n1-experiments-nutritional-ketosis-day-301-330/18195#comments"&gt;http://livinlavidalowcarb.c...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;Joe Fraizer • 5 hours ago&lt;br&gt;Jimmy, I have been following your blog for two years and have, until now, been too shy to comment. The pictures you posted, however, have inspired me to do so. You look unreal! You appear to be physically lean and appear to be closing in on an athletic physique. I am of Aboriginal descent, and the only success I have ever maintained with regards to weight loss has been via an approach similar to the methods you are currently using! Keep posting pictures man&lt;/p&gt;&lt;p&gt;LLVLCBlog Mod  Joe Fraizer • 5 hours ago&lt;/p&gt;&lt;p&gt;THANKS Joe! I feel more athletic than I have in my entire life...saying a lot since I'm past the age when most men would be in their prime for physique. But I'm bound and determined to keep pursuing this with a goal to see myself get stronger and stronger and one day see my abs for the first time. It's a BIG challenge, but I'm up for it now that I've found what is right for me. KEEP IT UP, Joe!&lt;/p&gt;&lt;p&gt;"You look unreal! You appear to be physically lean and appear to be closing in on an athletic physique."&lt;/p&gt;&lt;p&gt;JM wants to see his abs one day - OMG - he is still a fat tub of goo!!&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Wed, 10 Apr 2013 14:33:22 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20859055185L)#comment-859055185</link><description>&lt;p&gt;&lt;a href="http://www.drsinatra.com/heart-health-diet-main" rel="nofollow noopener" target="_blank" title="http://www.drsinatra.com/heart-health-diet-main"&gt;http://www.drsinatra.com/he...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;My heart-healthy PAM eating plan includes 45 to 50 percent slow-burning, low-glycemic index carbohydrates; 30 percent healthy fats; and 20 to 25 percent protein.  I’d also urge you to eat organic as much as possible. In short, here are some guidelines:&lt;/p&gt;&lt;p&gt;Increase your intake of:&lt;br&gt;Oatmeal and complex carbohydrate pastas, such as those made with whole wheat, spelt, or Jerusalem artichoke&lt;br&gt;Slow-burning, low-glycemic index vegetables, such as asparagus, broccoli, kale, Brussels sprouts, and spinach&lt;br&gt;Legumes, such as lentils, soybeans, and chickpeas (these contain folic acid, and they help lower insulin levels)&lt;br&gt;Onions and garlic (these contain allicin, which helps lower cholesterol levels)&lt;br&gt;Fresh herbs, such as rosemary, thyme, and basil&lt;br&gt;Fruits, such as cherries, peaches, plums, strawberries, blueberries, apricots, pears, and apples (melons, grapes, and kiwi are suitable, but they contain more sugar)&lt;br&gt;Sources of essential fatty acids (EFAs) and protein, such as cold-water fish and organic eggs&lt;br&gt;Soy products, such as tofu, soybeans, tempeh, and soy milk&lt;br&gt;Fish, especially fatty ones, such as salmon&lt;br&gt;Healthy fats, such as olive, sesame, walnut, avocado, and flax oils&lt;br&gt;Nuts and seeds, including walnuts, almonds, chestnuts, and flaxseed&lt;br&gt;Low-fat cottage cheese, feta cheese, and grated Parmesan&lt;br&gt;Decrease your intake of:&lt;br&gt;Foods containing refined white flour or sugar, such as breads and bagels&lt;br&gt;Partially hydrogenated oils, found in commercially prepared crackers, cookies, chips, and other snacks&lt;br&gt;Starchy vegetables such as corn, peas, and carrots&lt;br&gt;Canned vegetables, because they’re usually very high in sodium&lt;br&gt;Processed fruit juices, which are often loaded with sugars&lt;br&gt;Red meats and organ meats&lt;br&gt;Omega-6 oils, such as corn, safflower, sunflower, and canola&lt;br&gt;Full-fat dairy products, including whole milk and many cheeses&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Wed, 10 Apr 2013 17:32:04 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20859170838L)#comment-859170838</link><description>&lt;p&gt;So - logic would dictate that he REDUCE his intake of fat - Yes?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Wed, 10 Apr 2013 20:27:07 -0000</pubDate></item><item><title>Re: 20 Tips for Staying Low-Carb Healthy during the Holidays (and all year long!)</title><link>(u'https://www.diagnosisdiet.com/blog/category/ketogenic-diet',%20859733064L)#comment-859733064</link><description>&lt;p&gt;Anne should get a NMR test to see what her LDL-P and small LDL-P counts are.  Her Vit D levels are EXTREMELY low.  She should also test her ApoB levels.&lt;/p&gt;&lt;p&gt;The fact that her trigs are going up and her HDL is going dow is cause for concern as well&lt;/p&gt;&lt;p&gt;More info is needed  -ESPECIALLY the LDL-P and small LDL-P numbers&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Thu, 11 Apr 2013 10:55:13 -0000</pubDate></item><item><title>Re: Paleotard, meet potatotard, Op. 132</title><link>(u'http://caloriesproper.com/paleotard-meet-potatotard-op-132/',%20861149215L)#comment-861149215</link><description>&lt;p&gt;According to the chart the most weight was lost by adding additional servings of fruits, veggies, nuts and yogurt - so doesn't that mean that a lower saturated fat higher carbohydrate diet is better for weight loss than a higher saturated fat lower carbohydrate diet?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Fri, 12 Apr 2013 14:23:20 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Two Paleo Diets from Lindeberg's Group</title><link>(u'http://carbsanity.blogspot.com/2013/04/two-paleo-diets-from-lindebergs-group.html',%20861418493L)#comment-861418493</link><description>&lt;p&gt;Questions for the group&lt;/p&gt;&lt;p&gt;From Dr. Peter Attia's website - in the comments section&lt;/p&gt;&lt;p&gt;&lt;a href="http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-v" rel="nofollow noopener" target="_blank" title="http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-v"&gt;http://eatingacademy.com/nu...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;Thomas Dayspring aka "Dr Lipid" May 26, 2012&lt;/p&gt;&lt;p&gt;Well the 50th percentile cutpoint is not normal if one is trying to prevent atherosclerosis. The 20th percentile cutpoint would be considered desirable: that is 80 mg/dL for apoB and &amp;lt; 1000 nmol/L for LDL-P&lt;/p&gt;&lt;p&gt;Barkeater May 31, 2012&lt;/p&gt;&lt;p&gt;Thanks&lt;br&gt;for replying and thanks for this series.&lt;/p&gt;&lt;p&gt;I am anxious for the grand train wreck that comes when Dr. A tells Jimmy Moore and the low-carb/ paleo crowd that have achieved &amp;gt; 2000 LDL-Ps (yes, I am in that club, thanks to FH) that they have to get to an 1100 LDL-P, and good luck getting there with anything but statins or unproven crap like zetia (or maybe an Ornish diet – me, I choose to eat food). As TO&lt;br&gt;says, get your popcorn.&lt;/p&gt;&lt;p&gt;Jimmy Moore has gotten an NMR, and reported LDL-P of 2130. I see a significant number of low-carbers seem to have spikes in their LDL-C and LDL-P that would appear to be driven by diet. They are not necessarily FHers like me (but I have seen wide ranging LDL-P, from 1500 to 2800, and cannot yet tie it out to diet). Commenter MacKillop below refers to a double-digit percentage of folks on low-carb diets who see very high LDL-C. Mr. and Mrs.&lt;br&gt;Jaminet have blogged at some length on the issue. I see the view expressed by some that this phenomenon is due to ApoE4, but I don’t buy it (I am a 3/3).&lt;/p&gt;&lt;p&gt;Peter Attia May 31, 2012&lt;br&gt;The question we don’t know the answer to is if an LDL-P of 2,000 in someone who eats no carbs is the same as an LDL-P of 2,000 in someone who does. I had breakfast with Eric Westman today and we discussed this topic. Eric makes a pretty compelling case that these 2 states are not, in fact, the same thing. I think we can safely say we don’t know the answer. At least I don’t. I’ll keep looking for clues, though.&lt;/p&gt;&lt;p&gt;Peter Attia May&lt;br&gt;31, 2012&lt;br&gt;I completely agree with Eric’s assertion (in fact, I’m having breakfast with Eric in an hour). This brings up a much larger question that I’m sure I will detail more closely in this series: It is&lt;br&gt;possible that all of the risk stratification we have for heart disease is predicated on someone consuming a normal Western diet? Furthermore, is it possible that once the body stops relying on glycogen and turns over to metabolic pathways of ketosis that the “numbers” we target as “normal” are irrelevant? I think I know the answer for some physiologic parameters, but I’m still trying to develop my “universal theory” uniting it all.&lt;/p&gt;&lt;p&gt;MY questions are these&lt;/p&gt;&lt;p&gt;1) "is an LDL-P of 2,000 in someone who eats no carbs the same as an LDL-P of 2,000 in someone who does&lt;/p&gt;&lt;p&gt;2) "is it possible that all of the risk stratification we have for heart disease is predicated on someone consuming a normal Western diet? Furthermore, is it possible that once the body stops relying on glycogen and turns over to metabolic pathways of ketosis that the “numbers” we target as “normal” are irrelevant?"&lt;/p&gt;&lt;p&gt;OR&lt;/p&gt;&lt;p&gt;3) Is DR Thomas Dayspring right when he says "Well the 50th percentile cutpoint is not normal if one is trying to prevent atherosclerosis. The 20th percentile cutpoint would be considered desirable: that is 80 mg/dL for apoB and &amp;lt; 1000 nmol/L for LDL-P.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Fri, 12 Apr 2013 20:43:53 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Paleo Science and the Paleo Diet II</title><link>(u'http://carbsanity.blogspot.com/2013/04/paleo-science-and-paleo-diet-ii.html',%20862363137L)#comment-862363137</link><description>&lt;p&gt;Questions for the group&lt;/p&gt;&lt;p&gt;From Dr. Peter Attia's website - in the comments section&lt;/p&gt;&lt;p&gt;&lt;a href="http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-v" rel="nofollow noopener" target="_blank" title="http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-v"&gt;http://eatingacademy.com/nu...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;Thomas Dayspring aka "Dr Lipid" May 26, 2012&lt;/p&gt;&lt;p&gt;Well the 50th percentile cutpoint is not normal if one is trying to prevent atherosclerosis. The 20th percentile cutpoint would be considered desirable: that is 80 mg/dL for apoB and &amp;lt; 1000 nmol/L for LDL-P&lt;/p&gt;&lt;p&gt;Barkeater May 31, 2012&lt;/p&gt;&lt;p&gt;Thanks&lt;br&gt;for replying and thanks for this series.&lt;/p&gt;&lt;p&gt;I am anxious for the grand train wreck that comes when Dr. A tells Jimmy Moore and the low-carb/ paleo crowd that have achieved &amp;gt; 2000 LDL-Ps (yes, I am in that club, thanks to FH) that they have to get to an 1100 LDL-P, and good luck getting there with anything but statins or unproven crap like zetia (or maybe an Ornish diet – me, I choose to eat food). As TO&lt;br&gt;says, get your popcorn.&lt;/p&gt;&lt;p&gt;Jimmy Moore has gotten an NMR, and reported LDL-P of 2130. I see a significant number of low-carbers seem to have spikes in their LDL-C and LDL-P that would appear to be driven by diet. They are not necessarily FHers like me (but I have seen wide ranging LDL-P, from 1500 to 2800, and cannot yet tie it out to diet). Commenter MacKillop below refers to a double-digit percentage of folks on low-carb diets who see very high LDL-C. Mr. and Mrs.&lt;br&gt;Jaminet have blogged at some length on the issue. I see the view expressed by some that this phenomenon is due to ApoE4, but I don’t buy it (I am a 3/3).&lt;/p&gt;&lt;p&gt;Peter Attia May 31, 2012&lt;br&gt;The question we don’t know the answer to is if an LDL-P of 2,000 in someone who eats no carbs is the same as an LDL-P of 2,000 in someone who does. I had breakfast with Eric Westman today and we discussed this topic. Eric makes a pretty compelling case that these 2 states are not, in fact, the same thing. I think we can safely say we don’t know the answer. At least I don’t. I’ll keep looking for clues, though.&lt;/p&gt;&lt;p&gt;Peter Attia May&lt;br&gt;31, 2012&lt;br&gt;I completely agree with Eric’s assertion (in fact, I’m having breakfast with Eric in an hour). This brings up a much larger question that I’m sure I will detail more closely in this series: It is&lt;br&gt;possible that all of the risk stratification we have for heart disease is predicated on someone consuming a normal Western diet? Furthermore, is it possible that once the body stops relying on glycogen and turns over to metabolic pathways of ketosis that the “numbers” we target as “normal” are irrelevant? I think I know the answer for some physiologic parameters, but I’m still trying to develop my “universal theory” uniting it all.&lt;/p&gt;&lt;p&gt;My questions are these&lt;/p&gt;&lt;p&gt;1) "is an LDL-P of 2,000 in someone who eats no carbs the same as an LDL-P of 2,000 in someone who does&lt;/p&gt;&lt;p&gt;2) "is it possible that all of the risk stratification we have for heart disease is predicated on someone consuming a normal Western diet? Furthermore, is it possible that once the body stops relying on glycogen and turns over to metabolic pathways of ketosis that the “numbers” we target as “normal” are irrelevant?"&lt;/p&gt;&lt;p&gt;OR&lt;/p&gt;&lt;p&gt;3) Is DR Thomas Dayspring right when he says "Well the 50th percentile cutpoint is not normal if one is trying to prevent atherosclerosis. The 20th percentile cutpoint would be considered desirable: that is 80 mg/dL for apoB and &amp;lt; 1000 nmol/L for LDL-P.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sat, 13 Apr 2013 16:01:29 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Paleo Science and the Paleo Diet II</title><link>(u'http://carbsanity.blogspot.com/2013/04/paleo-science-and-paleo-diet-ii.html',%20862363562L)#comment-862363562</link><description>&lt;p&gt;As Aragorn asks - why is it okay to eat the muscle and organs of an animal whose milk you're not supposed to drink??&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sat, 13 Apr 2013 16:02:21 -0000</pubDate></item><item><title>Re: Does Carnitine from Red Meat Cause Heart Disease?</title><link>(u'https://www.diagnosisdiet.com/full-article/does-carnitine-from-red-meat-cause-heart-disease',%20863337621L)#comment-863337621</link><description>&lt;p&gt;With regard to CVD and the inuit&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.ncbi.nlm.nih.gov/pubmed/12535749" rel="nofollow noopener" target="_blank" title="http://www.ncbi.nlm.nih.gov/pubmed/12535749"&gt;http://www.ncbi.nlm.nih.gov...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;Abstract&lt;/p&gt;&lt;p&gt;BACKGROUND:&lt;/p&gt;&lt;p&gt;The notion that the incidence of ischemic heart disease (IHD) is low among the Inuit subsisting on a traditional marine diet has attained axiomatic status. The scientific evidence for this is weak and rests on early clinical evidence and uncertain mortality statistics.&lt;/p&gt;&lt;p&gt;METHODS:&lt;/p&gt;&lt;p&gt;We reviewed the literature and performed new analyses of the mortality statistics from Greenland, Canada, and Alaska.&lt;/p&gt;&lt;p&gt;FINDINGS:&lt;/p&gt;&lt;p&gt;The evidence for a low mortality from IHD among the Inuit is fragile and rests on unreliable mortality statistics. Mortality from stroke, however, is higher among the Inuit than among other western populations. Based on the examination of 15 candidate gene polymorphisms, the Inuit genetic architecture does not obviously explain putative differences in cardiovascular disease prevalence.&lt;/p&gt;&lt;p&gt;INTERPRETATION:&lt;/p&gt;&lt;p&gt;The mortality from all cardiovascular diseases combined is not lower among the Inuit than in white comparison populations. If the mortality from IHD is low, it seems not to be associated with a low prevalence of general atherosclerosis. A decreasing trend in mortality from IHD in Inuit populations undergoing rapid westernization supports the need for a critical rethinking of cardiovascular epidemiology among the Inuit and the role of a marine diet in this population.&lt;/p&gt;&lt;p&gt;From the full study - you can download the pdf via google scholar&lt;/p&gt;&lt;p&gt;&lt;a href="http://scholar.google.com/scholar?hl=en&amp;amp;q=Low+incidence+of+cardiovascular+disease+among+the+Inuit--what+is+the+evidence%3F&amp;amp;btnG=&amp;amp;as_sdt=1%2C33&amp;amp;as_sdtp=" rel="nofollow noopener" target="_blank" title="http://scholar.google.com/scholar?hl=en&amp;amp;q=Low+incidence+of+cardiovascular+disease+among+the+Inuit--what+is+the+evidence%3F&amp;amp;btnG=&amp;amp;as_sdt=1%2C33&amp;amp;as_sdtp="&gt;http://scholar.google.com/s...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;"we find the hypothesis that mortality from IHD is low among the Inuit compared with western populations insufficiently founded. Since mortality from stroke was higher among the Inuit and Alaska Natives than in the white comparison populations, a general statement that mortality from cardiovascular disease is high among the Inuit seems more warranted than the opposite.  In addition to our own genetic studies among the&lt;br&gt;Canadian Inuit, studies in Greenland have shown a low prevalence of certain apolipoprotein (a) isoforms consistent with a low genetic disposition for IHD [45], but&lt;br&gt;the genotype of the Inuit does not unequivocally indicate a population with a high or low predisposition for atherosclerosis.&lt;/p&gt;&lt;p&gt;The decrease in mortality from IHD in Greenland since 1965 is surprising in view of the rapid westernization of the country during the same period. A similar trend was present among Alaska Natives [13]. If this represents a real decrease in the incidence of IHD and not just a change in diagnostic habits or improved possibilities for treatment, it will be difficult to maintain the importance of the traditional marine diet for a low incidence of atherosclerosis and IHD in these populations."&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 14 Apr 2013 12:58:31 -0000</pubDate></item><item><title>Re: Andrew Kim Blog: PUFA, lipid peroxidation processes, and the implications for atherosclerosis and diet Part III</title><link>(u'http://www.andrewkimblog.com/2013/04/pufa-lipid-peroxidation-processes-and_14.html',%20863422234L)#comment-863422234</link><description>&lt;p&gt;Andrew - just curious - when you fed your data into cronometer what did you eat that day?&lt;/p&gt;&lt;p&gt;I'm curious as to your diet.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Sun, 14 Apr 2013 14:26:05 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Ancestral Rabbit Starvation Medical Vacations! The next craze?</title><link>(u'http://carbsanity.blogspot.com/2013/04/ancestral-rabbit-starvation-medical.html',%20867399429L)#comment-867399429</link><description>&lt;p&gt;Might the  Aborigines be genetically adapted to a higher protein diet?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Thu, 18 Apr 2013 16:54:16 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Ancestral Rabbit Starvation Medical Vacations! The next craze?</title><link>(u'http://carbsanity.blogspot.com/2013/04/ancestral-rabbit-starvation-medical.html',%20867404557L)#comment-867404557</link><description>&lt;p&gt;&lt;a href="http://www.bmj.com/content/346/bmj.f1050" rel="nofollow noopener" target="_blank" title="http://www.bmj.com/content/346/bmj.f1050"&gt;http://www.bmj.com/content/...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;The science of obesity: what do we really know about what makes us fat? An essay by Gary Taubes&lt;/p&gt;&lt;p&gt;"A year ago, working with Peter Attia, a physician, and with support from the Laura and John Arnold Foundation in Houston Texas, I co-founded a not-for-profit organisation called the Nutrition Science Initiative (&lt;a href="http://NuSI.org" rel="nofollow noopener" target="_blank" title="NuSI.org"&gt;NuSI.org&lt;/a&gt;). Our strategy is to fund and facilitate rigorously well controlled experimental trials, carried out by independent, skeptical researchers. The Arnold Foundation has now committed $40m over the next three years to this research programme. Our hope is that these experiments will be the first steps in answering definitively the question of what causes obesity and help us finally make meaningful progress against it.&lt;/p&gt;&lt;p&gt;We believe that ultimately three conditions are necessary to make progress in the struggle against obesity and its related chronic diseases—type 2 diabetes, most notably. First is the acceptance of the existence of an alternative hypothesis of obesity, or even multiple alternative hypotheses, with the understanding that these, too, adhere to the laws of physics and must be tested rigorously.&lt;/p&gt;&lt;p&gt;Second is a refusal to accept substandard science as sufficient to establish reliable knowledge, let alone for public health guidelines. When the results of studies are published, the authors must be brutally honest about the possible shortcomings and all reasonable alternative explanations for what they observed. “If science is to progress,” as the Nobel prize winning physicist Richard Feynman said half a century ago, “what we need is the ability to experiment, honesty in reporting results—the results must be reported without somebody saying what they would like the results to have been—and finally—an important thing—the intelligence to interpret the results. An important point about this intelligence is that it should not be sure ahead of time what must be.”20&lt;/p&gt;&lt;p&gt;Finally, if the best we’ve done so far isn’t good enough—if uncontrolled experiments and observational studies are unreliable, which should be undeniable—then we have to find the willingness and the resources to do better. With the burden of obesity now estimated at greater than $150bn (£100bn; €118bn) a year in the US alone, virtually any amount of money spent on getting nutrition research right can be defended on the basis that the long term savings to the healthcare system and to the health of individuals will offset the costs of the research by orders of magnitude."&lt;/p&gt;&lt;p&gt;Forty Million Dollars??  WOW.&lt;/p&gt;&lt;p&gt;Competing interests: I have read and understood the BMJ Group policy on declaration of interests and declare: I am employed by the Nutrition Science Initiative, a 501(3)c. NuSI does not accept support from the food industry. I received support (a book advance) from Random House Inc to do the research that is reported in this essay, and I have received honorariums and travel expenses from food industry and academic sources.&lt;/p&gt;&lt;p&gt;Question - What food industry sources??&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Thu, 18 Apr 2013 17:00:48 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Ancestral Rabbit Starvation Medical Vacations! The next craze?</title><link>(u'http://carbsanity.blogspot.com/2013/04/ancestral-rabbit-starvation-medical.html',%20868434092L)#comment-868434092</link><description>&lt;p&gt;Then - if the eskimos and the aborigines are genetically adapted to this type of diet then of what use are these studies to the rest of the world??&lt;/p&gt;&lt;p&gt;Also - what damage (long term) is being done by people following a VLCHF diet who are NOT genetically adapted?&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Fri, 19 Apr 2013 13:41:08 -0000</pubDate></item><item><title>Re: The Carb-Sane Asylum: Paleo™ *IS* a Fad Diet</title><link>(u'http://carbsanity.blogspot.com/2013/04/paleo-is-fad-diet.html',%20868796658L)#comment-868796658</link><description>&lt;p&gt;Here's a 2 year study AND a 4 year follow-up (so we're talking about a 6 year diet study?&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.nejm.org/doi/full/10.1056/NEJMoa0708681" rel="nofollow noopener" target="_blank" title="http://www.nejm.org/doi/full/10.1056/NEJMoa0708681"&gt;http://www.nejm.org/doi/ful...&lt;/a&gt;&lt;br&gt;Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet&lt;/p&gt;&lt;p&gt;&lt;a href="http://lowcarbdiets.about.com/od/science/a/studynejm708.htm" rel="nofollow noopener" target="_blank" title="http://lowcarbdiets.about.com/od/science/a/studynejm708.htm"&gt;http://lowcarbdiets.about.c...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;This study of mostly men in Israel took place over a two-year period. The participants were overweight or mildly obese, with BMIs averaging around 30 to 31. They were divided into three groups and given fairly intensive counseling on how to help them follow one of the diets. All study participants worked in the same place, and the workplace cafeteria developed special menus for the three groups that corresponded to the diets they were put on. Offerings were color-coded to make following the assigned diet during the day easy.&lt;/p&gt;&lt;p&gt;The three groups followed one of the following diets:&lt;/p&gt;&lt;p&gt;1. Low Fat Diet: A calorie-restricted diet with a maximum of 30% of the calories coming from fat, 10% from saturated fat, and 300 mg of cholesterol daily. "The participants were counseled to consume low-fat grains, vegetables, fruits, and legumes, and to limit their consumption of additional fats, sweets, and high-fat snacks."&lt;/p&gt;&lt;p&gt;2. Mediterranean Diet: A calorie-restricted diet with a goal of a maximum of 35% of the calories from fat, including 2 to 3 tablespoons of olive oil and a few nuts each day. The diet was to be "rich in vegetables and low in red meat, with poultry and fish replacing beef and lamb."&lt;/p&gt;&lt;p&gt;3. Low-Carb Diet: Based on the Atkins Diet, it began at 20 grams of carbohydrate per day, gradually increasing to 120 grams per day "to maintain weight loss." Calories, fat, and protein were not restricted. "However, the participants were counseled to choose vegetarian sources of fat and protein and to avoid trans fat."&lt;/p&gt;&lt;p&gt;Of those who finished the 2-year study, the low-carb diet edged out the other two diets, with a sustained average 12 lb. loss compared to 10 lbs. for the Mediterranean diet and 7 lbs. for the low-fat diet. Although the vast majority (86%) of the participants were men, the women had more weight loss on the Mediterranean diet.&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.nejm.org/doi/full/10.1056/NEJMc1204792" rel="nofollow noopener" target="_blank" title="http://www.nejm.org/doi/full/10.1056/NEJMc1204792"&gt;http://www.nejm.org/doi/ful...&lt;/a&gt;&lt;br&gt;Four-Year Follow-up after Two-Year Dietary Interventions&lt;/p&gt;&lt;p&gt;At 2 years, the adherence rate was 85%, with evidence of distinct dietary patterns in the three diet groups. After 2 years,1 the mean weight loss was 2.9 kg in the low-fat group, 4.4 kg in the Mediterranean group, and 4.7 kg in the low-carbohydrate group. In addition, we found that there was a significant diet-induced regression in volume in the carotid-vessel wall.4 After the 2-year intervention was completed, we followed the participants for 4 more years&lt;/p&gt;&lt;p&gt;&lt;a href="http://www.nejm.org/doi/suppl/10.1056/NEJMc1204792/suppl_file/nejmc1204792_appendix.pdf" rel="nofollow noopener" target="_blank" title="http://www.nejm.org/doi/suppl/10.1056/NEJMc1204792/suppl_file/nejmc1204792_appendix.pdf"&gt;http://www.nejm.org/doi/sup...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;We next performed an intention-to-treat analysis across the assigned diets, with 4-year follow-up among 259 participants (80.4% of the original group and 95.2% of those who had completed the 2-year trial). At 6 years after study initiation, 67% of the participants had continued with their originally assigned diet, 11% had switched to another diet, and 22% were not dieting (P=0.36 for all comparisons). During this follow-up period, participants had regained 2.7 kg of weight lost in the low-fat group, 1.4 kg in the Mediterranean group, and 4.1 kg in the low-carbohydrate group (P=0.004 for all comparisons).&lt;/p&gt;&lt;p&gt;&lt;a href="http://lowcarbdiets.about.com/b/2012/10/14/some-results-from-a-truly-long-term-diet-study.htm" rel="nofollow noopener" target="_blank" title="http://lowcarbdiets.about.com/b/2012/10/14/some-results-from-a-truly-long-term-diet-study.htm"&gt;http://lowcarbdiets.about.c...&lt;/a&gt;&lt;/p&gt;&lt;p&gt;The groups were further apart at the 2-year mark, with the low-carb group sustaining an average of 12 pounds lost at that point (10 for the Mediterranean group, 7 for the low-fat group). By the six-year point, those group retained 3.7, 6.8, and 1.3 lost pounds respectively.&lt;/p&gt;</description><dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">charles grashow</dc:creator><pubDate>Fri, 19 Apr 2013 21:06:17 -0000</pubDate></item></channel></rss>